Pavillon Jean-Coutu, Room 3196
Phone: 514-343-7966
Fax: 514-343-7073
E-mail : marc.servant@umontreal.ca

Teaching Domains

• Molecular Biology of the Cell

• Molecular Pharmacology

Research Themes

• Understanding the regulation and the role of effectors of the innate immune response in the context of chronic inflammatory diseases such as atherosclerosis, cancer and autoimmune diseases

Current Research Projects

• Role of the IKK complex in the proinflammatory and hypertrophic actions of Angiotensin II

 

• Role of the IKK-related kinases, TBK1 and IKKi, in the hypoxic response and oncogenesis

 

• Understanding the role and the regulation of the IKK-related kinase-IRF-3 pathway in autoimmune diseases

Selected Publications

 

Clement JF, Bibeau-Poirier A, Gravel SPi, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ. Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. Journal of Virology 2008;82:3984-3996.

Clément F, Meloche S, Servant MJ. The IKK-Related Kinases: Innate Immunity to Oncogenesis. Cell Research 2008;18:889-899.

Bibeau-Poirier A, Servant MJ. Roles of ubiquitination in pattern recognition receptors and type I interferon receptor signaling. Cytokine 2008;43:359-367.

Douillette A, Bibeau-Poirier A, Gravel SP, Clément JF, Chénard V, Moreau P, Servant MJ. The proinflammatory actions of Angiotensin II are dependent on p65 phosphorylation by the IKK complex. Journal of Biological Chemistry 2006;281:13275-13284.

Bibeau-Poirier A, Gravel SP, Clement JF, Rolland S, Rodier G, Coulombe P, Hiscott J, Grandvaux N, Meloche S, Servant MJ. Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation. Journal of Immunology 2006;177:5059-5067.

Lépicier P, Bibeau-Poirier A, Lagneux C, Servant MJ, Lamontagne D. Signalling pathways involved in the cardioprotective effects of canabinoids. Journal of Pharmacological Science 2006;102:155-166.

Gravel SP, Servant MJ. Roles of an IKK-related pathway in human cytomegalovirus-infected vascular smooth muscle cells: a molecular link in pathogens-induced proatherosclerotic conditions. Journal of Biological Chemistry 2005;280:7477-7486.

Servant MJ, Grandvaux N, ten Oever B, Duguay D, Lin R, Hiscott J. Identification of the minimal phosphoacceptor site required for in vivo activation of IRF-3 in response to virus and dsRNA. Journal of Biological Chemistry 2003;278:9441-9447.

 

Last update :  2010-07-26