Jacques Turgeon   Full Professor B. Pharm., Ph. D.

Research Director
CHUM - Hôtel-Dieu
Masson Pavillon, Room 8-107
3850, Saint-Urbain Street
Phone: 514-890-8044
E-mail: jacques.turgeon@umontreal.ca

Teaching Domains

• Drug metabolism

• Pharmacogenetics

• Pharmacocinetics

• Cardiac electrophysiology

Research Themes

• Intersubject variability in drug action

• Pharmacogenetics and drug metabolism

• Cardiac electrophysiology

• Proarrhytmia mechanisms

Current Research Projects

• Genetics polymorphisms and Warfarin use

• ABC transporters and cardiac drug action

• CYP450 Isozymes and drug metabolism in the heart

• Drug-interactions involving CYP450s and membrane transporters

Selected Publications

Colucci P, Pottage JC, Robison H, Turgeon J, Ducharme MP. Effect  of a Single Dose of itonavir on the Pharmacokinetic Behavior of Elvucitabine, a Nucleoside Reverse Transcirptase Inhibitor, Administered in Healthy Volunteers. Antimicrob Agents Chemother 2009;53(2):646-650.

Colucci P, Pottage JC, Robison H, Turgeon J, Schürmann D, Hoepelman IM, Ducharme MP. Multiple-Dose Pharmacokinetic Behavior of Elvucitabine, a Nucleoside Reverse Transcriptase Inhibitor, Administered over 21 Days with Lopinavir-Ritonavir in Human Immunodeficiency Virus Type 1 – Infected Subjects. Antimicrob Agents Chemother 2009;53(2):662-669.

Lordkipanidzé M, Diodati JG, Turgeon J, Schampaert E, Palisaitis DA, Pharand C. Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin. Int J Cardiol 2009, doi:10.1016/j.icard.2009.01.037.

Fenneteau F, Turgeon J, Couture L, Michaud V, Li J, Nekka F. Assessing drug distributrion in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modelling: model structure and parameters determination. Theor Biol Med Model 2009;15(6):1-2.

Hreiche R, Morissette P, Zakrzewski-Jakubiak H, Turgeon J. Gender-related differences in drug-induced prolongation of cardiac repolization in prepubertal ginea pigs. J Cardiovascular Pharmacol Ther 2009;14(1):28-37.

Hreiche R, Michaud V, Turgeon J. The role of ethnicity in managing cardiovascular patients.  Cardiovascular Genetics and Genomics, Roden D.M. editor. American Heart Association Monographs 2008; Chapter 3, pp.33-47.

Hreiche R, Morissette P, Turgeon J. Drug-induced Long QT Syndrome in women: Review of current evidence and remaining gaps. Gender Medicine 2008;5(2):124-35.

de Denus S, Zakrzewski-Jakubiak M, Dubé MP, Bélanger F, Lepage S, Leblanc MH, Gossard D, Ducharme A, Racine N, Whittom L, Lavoie J, Touyz R, Turgeon J, White M.  Effects of AGTR1 A1166C gene polymorphism in patients heart failure treated with Candesartan.  Ann Pharmacother 2008(42):925-32.

Last update :  2010-04-14