Pavillon J.-A.-Bombardier, Local 4075
Téléphone: 514-340-5179
Télécopieur: 514-340-3145
Courriel: francoise.winnik@umontreal.ca

Thèmes d’enseignement

• chimie medicinale

• chimie physique

Thèmes de recherche

• vecteurs pour médicaments

• relargage contrôlé de médicaments

• thérapie génique

• imagerie médicale

Principaux projets de recherche en cours

• micelles polymères bioadhésives et leur rôle en formulations orales

• nanoparticules pour la thérapie génique

• applications médicales des multicouches de polyélectrolytes

• applications médicales de polysaccharides modifiés

Publications représentatives

Soliman GM, Winnik FM. Enhancement of hydrophilic drug loading and release characteristics through micellization with new carboxymethyldextran-PEG block copolymers of tunable charge density. Int J Pharm 2008;356:248–258.

Diab C, Tribet C, Gohon Y, Popot JL, Winnik FM. Complexation of integral membrane proteins by phosphorylcholine-based amphipols. Biochim Biophys Acta, Biomembranes 2007;1768(11):2737-2747.

Cho SJ, Maysinger D, Jain M, Roeder B, Hackbarth S, Winnik FM. Long-Term Exposure to CdTe Quantum Dots Causes Functional Impairments in Live Cells. Langmuir 2007;23(4):1974-1980.

Tiera MJ, Qiu XP, Bechaouch S, Shi Q, Fernandes J, Winnik FM. Synthesis and characterization of phosphorylcholine-substituted chitosans soluble in physiological conditions. Biomacromolecules 2006;7:3151-3156.

Kujawa P, Tanaka F, Winnik FM. Temperature-dependent properties of telechelic hydrophobically modified poly(N-isopropylacrylamides) in water: evidence from light scattering and fluorescence spectroscopy for the formation of stable mesoglobules at elevated temperatures. Macromolecules 2006;39(8):3048-3055.

Lovric J, Cho SJ, Winnik FM, Maysinger D. Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death. Chem Biol 2005;12(11):1227-1234.

Francis MF, Cristea M, Winnik FM. Exploiting the Vitamin B12 Pathway to enhance oral drug delivery via polymeric micelles. Biomacromolecules 2005;6(5):2462-2467.

Kujawa P, Moraille P, Sanchez J, Badia A, Winnik FM. Effect of molecular weight on the exponential growth of chitosan/hyaluronan multilayers: a surface plasmon resonance and atomic force microscopy investigation. J Amer Chem Soc 2005;127(25):9224-9234.