Daniel Lévesque     Full Professor Ph. D. (Pharmacy)

Pavillon Jean-Coutu, Room 3216
Phone: 514-343-6339
Fax: 514-343-7073
E-mail: daniel.levesque.1@umontreal.ca

Teaching Domains

• Pharmacology
• Molecular and cellular biology
• Neurosciences
• Central nervous system drugs

Research Themes

• Neuropharmacology
• Schizophrenia
• Parkinson's disease
• Antipsychotic and anti-parkinsonian drugs

Current Research Projects

• Role of nuclear receptors in antipsychotic drug actions (Stanley Medical research Institute, USA)
• Pharmacology of antipsychotic drugs-induced dyskinesias (CIHR)
• Nuclear receptors and dopamine neurotransmission (CIHR)

Selected Publications

Bourhis E, Maheux J, Paquet B, Kagechika H, Shudo K, Rompré PP, Rouillard C, Lévesque D. The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activites. Psycopharmacology 2009;202:635-648.

Lévesque D, Rouillard C. Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation. Trends Neurosci 2007;30:22-30.

Gilbert F, Morissette M, St-Hilaire M, Paquet B, Rouillard C, Di Paolo T, Lévesque D. Role of Nur77 in dopamine neuron biochemical activity and dopamine turnover. Biol Psychiatry 2006;60:538-547.

Samadi P, Grégoire L, Rouillard C, Bédard PJ, Di Paolo T, Lévesque D. Docosahexaenoic acid (DHA) reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkeys. Annals Neurol 2006;59:282-288.

Van den Munckhof P, Gilbert F, Lévesque D, Drouin J. Rescue of locomotor deficit by L-DOPA in Aphakia mice, a model of Parkinson’s disease. J Neurochem 2006;96:160-170.

St-Hilaire M, Bourhis E, Lévesque D, Rouillard C. Impaired behavoural and molecular adaptations to dopamine denervation and repeated L-DOPA treatment in Nur77 knockout mice. Eur J Neurosci 2006;24:795-805.

Maheux J, Éthier I, Rouillard C, Lévesque D. Typical and atypical antipsychotic drugs induce distinct patterns of expression of transcription facteurs of the Nur family (Nur77, Nurr1 and Nor-1): Implication for their mechanism of action. J Pharmaco. Exp Ther 2005;313:460-473.

Éthier I, Kagechika H, Shudo K, Rouillard C, Lévesque D. Docosahexaenoic Acid Reduces Haloperidol-Induced Dyskinesias in Mice: Involvement of Nur77 and Retinoid Receptors. Biol Psychiatry 2004;56:522-526.

Éthier I, St-Hilaire M, Beaudry G, Milbrandt J, Rouillard C, Lévesque D. The transcription factors NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and neuropeptide gene expression. Neuropsychopharmacology 2004;29:335-346.

Last update :  2010-04-13