Jean-Coutu Pavillon, Room 3201
Telephone: 514-343-6111 #0792
Fax: 514-343-7073
Email: denis.deblois@umontreal.ca

 

Teaching Domains

• Pharmacology
• Drug Discovery and Development
• Vascular Biology
• Inflammation

Research Themes

• Mechanisms of cardiovascular remodeling
• Balance between cell growth and apoptosis
• Endothelial dysfunction
• Hypertension, angioplasty

Current Research Projects

• Kinin B1 receptor as a signaling node for vascular protection in disease: implications for drug discovery
• Mechanisms of erectile dysfunction associated with early metabolic syndrome and hypertension
• Mechanisms of salt-induced vascular hyperplasia

Selected Publications

Lemay J, Hale TM, deBlois D. Neointimal-specific induction of apoptosis by losartan results in regression of vascular lesion in rat aorta. Eur J Pharmacol 2009;618(1-3):45-51.

Wang X, Adams LD, Pabon LM, Mahoney WM Jr, Beaudry D, Gunaje J, Geary RL, deBlois D, Schwartz SM. RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy. J Mol Cell Cardiol 2008;44(3):539-550.

Duguay D, Pesant S, Deschepper CF, deBlois D. Fibroblast apoptosis precedes cardiomyocyte mass reduction during left ventricular remodeling in hypertensive rats treated with amlodipine. J Hypertens 2007;25(6):1291-1299.

Duguay D, deBlois D. Differential regulation of Akt, caspases and MAP kinases underlies smooth muscle cell apoptosis during aortic remodelling in SHR treated with amlodipine. Br J Pharmacol 2007;151(8):1315-1323.

Dutil J, Eliopoulos V, Marchand EL, Devlin AM, Tremblay J, Prithiviraj K, Hamet P, Migneault A, deBlois D, Deng AY. A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate. Physiol Genomics 2005;21(3):362-369.

deBlois D, Tea BS, Beaudry D, Hamet P. Regulation of therapeutic apoptosis: a potential target in controlling hypertensive organ damage. Can J Physiol Pharmacol 2005;83(1):29-41.

Der Sarkissian S, Marchand EL, Duguay D, deBlois D. Synergistic interaction between enalapril, L-arginine and tetrahydrobiopterin in smooth muscle cell apoptosis and aortic remodeling induction in SHR. Br J Pharmacol 2004;142(5):912-918.

Marchand EL, Der Sarkissian S, Hamet P, deBlois D. Caspase-dependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats. Circ Res 2003;92(7):777-784.

 

 

Dernière modification:  2010-02-09